Venster will give you small efficient Python access to the Win32 libraries. Oh, and you’ll need this tutorial; venster is still about as easy to use as Win32, unfortunately.
Py2Exe then allows you to easily wrap these up into a binary distributable file for Windows.
Now choose the Windows deployment technology of your choice. (With a binary EXE, you actually have several good options.)
Non-Python development tools for Windows now have some work to do, if they want to curry favor with Windows developers.
Enjoy!
- Edward